![Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA) Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)](https://nida.nih.gov/sites/default/files/styles/content_image_medium/public/images/valenza_zamarripa_promo.jpg?itok=HRbtRBEw)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)
![Frontiers | Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective Frontiers | Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective](https://www.frontiersin.org/files/Articles/551365/fphar-11-01078-HTML/image_m/fphar-11-01078-g001.jpg)
Frontiers | Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective
![Study provides clues for designing new anti-addiction medications | National Institutes of Health (NIH) Study provides clues for designing new anti-addiction medications | National Institutes of Health (NIH)](https://www.nih.gov/sites/default/files/styles/featured_media_breakpoint-medium/public/news-events/news-releases/2012/kappa%2B%2B%2BJDTic.jpg?itok=UG811BuT×tamp=1443726961)
Study provides clues for designing new anti-addiction medications | National Institutes of Health (NIH)
![Narcotic Addiction in Failed Back Surgery Syndrome - Yuan-Chuan Chen, Ching-Yi Lee, Shiu-Jau Chen, 2019 Narcotic Addiction in Failed Back Surgery Syndrome - Yuan-Chuan Chen, Ching-Yi Lee, Shiu-Jau Chen, 2019](https://journals.sagepub.com/cms/10.1177/0963689718796072/asset/images/large/10.1177_0963689718796072-fig1.jpeg)
Narcotic Addiction in Failed Back Surgery Syndrome - Yuan-Chuan Chen, Ching-Yi Lee, Shiu-Jau Chen, 2019
![Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0278584615000020-gr1.jpg)
Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment - ScienceDirect
![A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0223523422006870-ga1.jpg)
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse - ScienceDirect
![Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine Dependence - ScienceDirect Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine Dependence - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-B978012420118700010X-f10-01-9780124201187.jpg)
Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine Dependence - ScienceDirect
![A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0031942217300420-fx1.jpg)
A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect
![Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat | Request PDF Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat | Request PDF](https://i1.rgstatic.net/publication/338464183_Effects_of_Kappa_opioid_receptor_blockade_by_LY2444296_HCl_a_selective_short-acting_antagonist_during_chronic_extended_access_cocaine_self-administration_and_re-exposure_in_rat/links/5f7443faa6fdcc0086487b30/largepreview.png)
Effects of Kappa opioid receptor blockade by LY2444296 HCl, a selective short-acting antagonist, during chronic extended access cocaine self-administration and re-exposure in rat | Request PDF
![Frontiers | Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System Frontiers | Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System](https://www.frontiersin.org/files/Articles/856672/fphar-13-856672-HTML/image_m/fphar-13-856672-g001.jpg)
Frontiers | Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System
![The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/d47b6fb7-e8b2-4af5-af57-9392445d2faf/jnc14612-fig-0005-m.png)
The blocking of kappa‐opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization - Azocar - 2019 - Journal of Neurochemistry - Wiley Online Library
![Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.9b00195/asset/images/large/cn-2019-00195v_0008.jpeg)
Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience
![Psychoactives | Free Full-Text | The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol Psychoactives | Free Full-Text | The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol](https://www.mdpi.com/psychoactives/psychoactives-01-00006/article_deploy/html/images/psychoactives-01-00006-g001.png)
Psychoactives | Free Full-Text | The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol
![Pharmaceuticals | Free Full-Text | Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction Pharmaceuticals | Free Full-Text | Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction](https://pub.mdpi-res.com/pharmaceuticals/pharmaceuticals-15-00214/article_deploy/html/images/pharmaceuticals-15-00214-g001-550.jpg?1644559817)
Pharmaceuticals | Free Full-Text | Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction
![A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41386-017-0006-4/MediaObjects/41386_2017_6_Fig1_HTML.jpg)